This clue appeared in the NYT Crossword on Thursday, November 27, 2025 (37 Across). The answer is hidden below until you want it. Thursday puzzles often have a trick, such as a rebus (several letters in one square) or answers that bend the rules.
Answer length: 5 squares
First letter
S _ _ _ _
First and last letters
S _ _ _ M
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About the answer
SERUM as a word: Blood serum used as a blood product, in the practice of medicine: blood serum from the tissues of immunized animals (human or nonhuman), containing antibodie...; (skincare) A skincare product of varying consistencies with a high concentration of one or more active ingredients, for a targeted purpose, such as preventin....
SERUM has been an answer 4 times in the NYT Crossword and Mini since October 27, 2025.
Other clues with the same answer
More clues from this puzzle
- Good person to give a time-consuming project, maybe (29 Across)
- St. ___ (city on a bay, informally) (34 Across)
- Latin for "but" (35 Across)
- One way to live (36 Across)
- "Tee" follower (38 Across)
- Greek theater (39 Across)
- In ___ (developing) (40 Across)
- Like nonagenarians (41 Across)
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