This clue appeared in the NYT Crossword on Sunday, November 9, 2025 (75 Across). The answer is hidden below until you want it. Sunday puzzles are large (21 by 21) and themed, about as hard as a Wednesday or Thursday.
Answer length: 5 squares
First letter
S _ _ _ _
First and last letters
S _ _ _ M
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About the answer
SERUM as a word: Blood serum used as a blood product, in the practice of medicine: blood serum from the tissues of immunized animals (human or nonhuman), containing antibodie...; (skincare) A skincare product of varying consistencies with a high concentration of one or more active ingredients, for a targeted purpose, such as preventin....
SERUM has been an answer 4 times in the NYT Crossword and Mini since October 27, 2025.
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