This clue appeared in the NYT Crossword on Thursday, January 1, 2026 (47 Across). The answer is hidden below until you want it. Thursday puzzles often have a trick, such as a rebus (several letters in one square) or answers that bend the rules.
Answer length: 3 squares
First letter
E _ _
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About the answer
EPI as a word: (medical jargon) epinephrine; A syringe or autoinjector filled with epinephrine, most frequently used for the treatment of acute allergic reactions to avoid or treat the onset of anaphyla....
EPI has been an answer 7 times in the NYT Crossword and Mini since December 13, 2025.
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