This clue appeared in the NYT Crossword on Tuesday, April 21, 2026 (3 Down). The answer is hidden below until you want it. Tuesday puzzles are a step up from Monday but still mostly straightforward.
Answer length: 3 squares
First letter
E _ _
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About the answer
EPI as a word: (medical jargon) epinephrine; A syringe or autoinjector filled with epinephrine, most frequently used for the treatment of acute allergic reactions to avoid or treat the onset of anaphyla....
EPI has been an answer 7 times in the NYT Crossword and Mini since December 13, 2025.
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