This clue appeared in the NYT Crossword on Sunday, October 26, 2025 (88 Down). The answer is hidden below until you want it. Sunday puzzles are large (21 by 21) and themed, about as hard as a Wednesday or Thursday.
Answer length: 4 squares
First letter
A _ _ _
First and last letters
A _ _ E
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About the answer
ACNE as a word: (pathology) A skin condition, usually of the face, that is common in adolescents. It is characterised by red pimples, and is caused by the inflammation of se...; A pattern of blemishes in an area of skin resulting from the skin condition.
ACNE has been an answer 12 times in the NYT Crossword and Mini since October 26, 2025.
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