This clue appeared in the NYT Crossword on Wednesday, December 17, 2025 (49 Across). The answer is hidden below until you want it. Wednesday sits mid-week in difficulty, with more wordplay than Monday or Tuesday.
Answer length: 3 squares
First letter
P _ _
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About the answer
PSA as a word: (medicine, immunology) Initialism of prostate-specific antigen. [(medicine) A glycoprotein enzyme secreted by the epithelial cells of the prostate gland and ...; Initialism of public service announcement. [(broadcasting) An advertisement intended to serve the public interest by raising awareness of an issue, affecting....
PSA has been an answer 9 times in the NYT Crossword and Mini since November 1, 2025.
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