This clue appeared in the NYT Crossword on Saturday, November 15, 2025 (58 Across). The answer is hidden below until you want it. Saturday puzzles are the hardest of the week and themeless, so clues are often deliberately misleading.
Answer length: 4 squares
First letter
M _ _ _
First and last letters
M _ _ O
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About the answer
MISO as a word: A thick paste made by fermentation of soybeans with the mold Aspergillus oryzae, used in making soups and sauces; (pharmacology, informal) Clipping of misoprostol. [(pharmacology) A drug used for various purposes including the prevention of drug-induced gastric ulcers an....
MISO has been an answer 4 times in the NYT Crossword and Mini since November 15, 2025.
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