This clue appeared in the NYT Crossword on Sunday, November 23, 2025 (108 Down). The answer is hidden below until you want it. Sunday puzzles are large (21 by 21) and themed, about as hard as a Wednesday or Thursday.
Answer length: 3 squares
First letter
E _ _
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About the answer
EDS as a word: (medicine) Initialism of Ehlers-Danlos syndrome. [(medicine, pathology) Any of a group of inherited connective tissue disorders caused by a defect in the syn...; (medicine) Initialism of excessive daytime sleepiness.
EDS has been an answer 8 times in the NYT Crossword and Mini since November 23, 2025.
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