This clue appeared in the Mini Crossword on Wednesday, October 7, 2026 (8 Across). The answer is hidden below until you want it.
Answer length: 4 squares
First letter
S _ _ _
First and last letters
S _ _ S
Show the answer
About the answer
SIRS as a word: Abbreviation of systemic inflammatory response syndrome.
SIRS has been an answer once in the NYT Crossword and Mini puzzles we have on file, which go back to October 23, 2025.
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