This clue appeared in the NYT Crossword on Thursday, October 22, 2026 (46 Down). The answer is hidden below until you want it. Thursday puzzles often have a trick, such as a rebus (several letters in one square) or answers that bend the rules.
Answer length: 6 squares
First letter
O _ _ _ _ _
First and last letters
O _ _ _ _ E
Show the answer
About the answer
OPIATE as a word: (pharmacology) A drug, hormone or other substance derived from or related to opium; (pharmacology) Relating to, resembling, or containing opium.
OPIATE has been an answer 2 times in the NYT Crossword and Mini since February 26, 2026.
Other clues with the same answer
More clues from this puzzle
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- Team with the most Super Bowl wins in the 1970s (41 Down)
- "Seriously!" (43 Down)
- Alternative to boo (45 Down)
- Brando with two Oscars (47 Down)
- Took big steps (48 Down)
- Big blowout (49 Down)
- ___ de asador (Mexican meal) (52 Down)
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